KMID : 0670820110160010001
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Korean Journal of Medical Mycology 2011 Volume.16 No. 1 p.1 ~ p.8
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A Study of Potential Application of Rubus coreanus Miquel Extract for Seborrheic Dermatitis Treatment
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Lim Yun-Young
Jang Woo-Sun Kim Hyeong-Mi Kim Min-Young Oh Sang-Ah Park Jin-Oh Kim Youn-Tae Park Jong-Ho Chun Young-Jin Lee Ji-Won Moon Kwon-Ki Kim Beom-Joon Kim Myeung-Nam Park Young-Min Kang Hoon
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Abstract
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Background: Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect. Objective: We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro.
Methods: Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M. slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2 weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2 weeks later.
Results: Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn¡¯t show antimicrobial effect to Malassezia globosa. However, Rubus coreanus Miquel Extract showed anti-inflammatory effect.
Conclusion: In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.
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KEYWORD
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Malassezia, Seborrheic dermatitis, Rubus coreanus Miquel
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